Category: News

The DIDB Concomitant Meds Navigator has been updated in January 2026 and is available in the Tools.

This update includes characterization of 54 compounds, encompassing substrates of CYP2D6, CYP3A, UGTs, OATP1B1, and OATP1B3 (N = 10); inhibitors of CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A, UGTs, P-gp, BCRP, OATP1B1, and OATP1B3 (N = 28); and inducers of CYP3A and UGTs (N = 16). One drug was identified as a strong CYP3A inhibitor and one as a strong CYP3A inducer based on dedicated DDI studies with midazolam. No sensitive substrates were identified. No drugs related to renal transporters were identified in this update.

In addition, a comprehensive review of UGT-related data curated in DIDB resulted in the characterization of 3 drugs as UGT substrates, 11 as UGT inhibitors, and 13 as UGT inducers, supported by DDI or pharmacogenetic data.

You may access the Navigator to view the full list of compounds, along with supporting study details and additional pharmacokinetic information.

As always, feel free to contact us if you have any questions or comments.

In December, we added 97 citations in DIDB, including 43 in vitro (with 25 articles published in December 2025) and 54 in vivo articles (with 30 articles published in December 2025).

3 NDAs approved by the FDA in September and October 2025, including nerandomilast (JASCAYD), paltusotine (PALSONIFY), and remibrutinib (RHAPSIDO) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In November, we added 101 citations in DIDB, including 51 in vitro (with 22 articles published in November 2025) and 50 in vivo articles (with 32 articles published in November 2025).

3 NDAs approved by the FDA in August and September 2025, including elamipretide (FORZINITY), imlunestrant (INLURIYO), rilzabrutinib (WAYRILZ) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In October, we added 102 citations in DIDB, including 45 in vitro (with 19 articles published in October 2025) and 57 in vivo articles (with 27 articles published in October 2025).

3 NDAs approved by the FDA in August 2025, including donidalorsen (DAWNZERA), dordaviprone (MODEYSO), and ZONGERTINIB (HERNEXEOS) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In September, we added 116 citations in DIDB, including 51 in vitro (with 25 articles published in September 2025) and 65 in vivo articles (with 45 articles published in September 2025).

3 NDAs approved in September 2025, including Brensocatib (BRINSUPRI), Sebetralstat (EKTERLY), and Aceclidine (VIZZ) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In Aug, we added 124 citations in DIDB, including 69 in vitro (with 23 articles published in August 2025) and 55 in vivo articles (with 29 articles published in August 2025).

3 NDAs approved in July 2025, including delgocitinib (ANZUPGO), sunvozertinib (ZEGFROVY), and sepiapterin (SEPHIENCE) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In July, we added 86 citations in DIDB, including 53 in vitro (with 17 articles published in July 2025) and 33 in vivo articles (with 32 articles published in July 2025).

3 NDA/BLAs approved in June 2025, including clesrovimab (ENFLONSIA), garadacimab (ANDEMBRY), and taletrectinib (IBTROZI) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In June, we added 110 citations in DIDB, including 51 in vitro (with 22 articles published in June 2025) and 59 in vivo articles (with 28 articles published in June 2025).

3 NDA/BLAs approved in May 2025, including avutometinib and defactinib (AVMAPKI FAKZYNJA CO-PACK), acoltremon (TRYPTYR), and telisotuzumab vedotin (EMRELIS) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In May, we added 122 citations in DIDB, including 62 in vitro (with 19 articles published in May 2025) and 60 in vivo articles (with 35 articles published in May 2025).

3 NDA/BLAs approved in 2025, including atrasentan (VANRAFIA), fitusiran (QFITLIA), and nipocalimab (IMAAVY) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.

In April, we added 128 citations in DIDB, including 67 in vitro (with 15 articles published in April 2025) and 61 in vivo articles (with 29 articles published in April 2025).

3 NDA approved in 2025, including gepotidacin (BLUJEPA), mirdametinib (GOMEKLI), and vimseltinib (ROMVIMZA) were also curated in DIDB.

You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.

As always, feel free to contact us if you have any questions or comments.