Watch our collection of short video tutorials

We have initiated a [How to]… Series of 2-min videos, to show how to search, explore, use, some specific content in DIDB. So far, we have recorded videos on combination drugs, racemate and enantiomers, QT interval prolongation, and drug monographs.

If you have in mind any information you find difficult to retrieve in DIDB, feel free to let us know at didbase@uw.edu. We will get back to you and can decide to explain it in a short video.

The videos are available in DIDB Resource Center. Please note that you must be signed in to access.

Watch our comprehensive DIDB demonstration

We have recorded a one-hour long video tutorial suitable as a refresher training or to kick-start the use of DIDB. It starts by introducing the different lists available in the Resource Center of DIDB and then, it shows how to retrieve the human in vitro metabolism and transport information using preformulated queries. Finally it presents the in vivo datasets and how to retrieve clinical PK-based information from drug-drug interaction, food-effect, organ impairment and pharmacogenetics studies.

The video is available in DIDB Resource Center. Please note that you must be signed in to access.

In vivo prediction tool available for evaluation

We are pleased to provide access to an innovative online tool: DDPred, developed by the University of Lyon, France, that uses an in vivo static mechanistic model to predict PK-based DDIs with hundreds of substrates and inhibitors/inducers and evaluates the impact of polymorphism.

The link to this application will be available to all DIDB users during a 6-month evaluation. Please take the time to test it and to provide your feedback in the online survey. We value your feedback! Thank you.

New features! Drug characteristics, advanced table search, and more

DIDB has been updated with the following new features:

  • Drug characteristics, e.g., substrate sensitivity, precipitant inhibition/induction potency, NTR, QT interval prolongation potential, are added into the drug monograph
  • A list of drugs with identified drug characteristics are presented in the Resource Center
  • “Advanced table search” function is added to filter the query results (in table view). See our updated video tutorial.

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New features! New filtering option on tables, in vitro transporter data in all drug queries, and more.

DIDB has been updated with the following new features:

  • Select filter added to Table view results
  • Query results presented in Table view first
  • Revised overall effect descriptions
  • Drug queries > Objects or Precipitants now support selecting multiple drugs (previous multiple objects/precipitants queries removed)
  • In vitro transport data added to all the Drug queries including Objects, Precipitants, and Object and precipitant Pair
  • In vitro transporter IC50 and Ki queries updated and % inhibition query added
  • In vivo transporter queries now take multiple elements
  • In vitro induction now has down regulation effect
  • FDA clinical index data updated

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New features! Full text search, food effect studies, and more

DIDB has been updated with the following new features:

Feel free to contact us at didbase@uw.edu if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New queries available for beta testing

New queries are now available for beta testing under “FDA Marker Queries”. They allow you to search for in vitro and clinical data for inhibitors of CYP markers, and, in a second step from the query results page, view clinical concentrations of each inhibitor.

We are looking forward to your feedback!

Upcoming release of new features on April 6, 2019!

The DIDB Team will release new features on Saturday April 6, 2019. The release includes the following improvements:

  • Revised home page with a new “Latest NDAs entered” section.
  • Added number of entries (studies) to standard citation info.
  • Added new monograph page for all compounds.
    • This new monograph page combines the previously separate PK summary, QT summary, and monograph into a single page.
    • What was formerly known as “Monograph” is now “DDI summary” and has been renamed throughout application.
    • New monograph page also aggregates some other additional information on each compound such as DIDB defined compound relationships, other properties from DIDB, and some selected external resources.
    • Every compound has a monograph page, but many compounds may not have a DDI, PK, or QT summary, so there may be very little information presented.
  • In Resource Center, added listings of all compounds in each therapeutic class, including DDI risk information.  This new therapeutic class information is a replacement for the DDI risk information which was presented in the Disease section.   The entire Disease section has been removed.
  • In Resource Center, added two new listings – all compounds with DDI Summaries and all compounds with PK Profiles.
  • Removed pdf product labels and replaced with link to Drugs@FDA when an NDA is related to the drug.

Do not hesitate to contact us at didbase@uw.edu if you have any feedback or questions!