New features! Drug Characteristics now integrated in queries

DIDB Drug Characteristics include several key drug properties such as:

  • substrate sensitivity, 
  • precipitant potency, 
  • QT prolongation, 
  • narrow therapeutic index. 

These characteristics are now embedded in most query results and are presented for both the object and the precipitant drugs, if applicable. 

The addition of drug characteristics to the table of results provides contextual information enabling a better understanding of the drug-drug interaction data and its clinical relevance.

As the next step, drug characteristics will power DIDB searches. To start, two in vivo queries are now enabling users to search using object or precipitant characteristics

  • the “Percent Change in AUC or CL” queries with Objects, 
  • the “Percent Change in AUC or CL” queries with Precipitants,

Please contact us if you find this new feature useful before we expand it to additional queries. As always, your feedback is critical to make the most of the DIDB content and functionalities!

New features! AUC and Cmax (90% CI) data, PGx-FDA label, and more

DIDB has been updated with the following new features:

  • AUC and Cmax GMRs (90% CI) are now systematically presented in the study results view (when available) and are used to calculate changes in exposure data
  • Links to PGx external resources have been added to pharmacogenetics queries to provide users with additional contextual information
  • New drug characteristic “PGx (FDA label)” highlights drugs with PGx-related recommendations in FDA label
  • Continuous expansion of compound PK parameters

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New Name and Additional Data! for the CYP/P-gp Substrates and Perpetrators Lists

Our new “DDI Marker Studies Knowledgebase” (in Excel) is now available in the Resource Center and replaces the previous combined and individual lists of CYP/P-gp substrates and perpetrators.

The Knowledgebase represents a comprehensive list of compounds that are sensitive or moderate sensitive substrates (NEW), inhibitors, or inducers of CYP enzymes (weak-to-strong potency assigned) and the P-gp transporter.

You can generate an individual list of a specific CYP isoform or transporter as shown in the video (at the bottom of the page).

Additionally, the Knowledgebase provides useful information on the compounds therapeutic class, clinical recommended dosage, pharmacokinetics (e.g., dose proportionality, accumulation ratio, time to steady-state), QT prolongation, and NTI characteristics.

The Knowledgebase will be updated quarterly.

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New features! and improvement of existing queries

DIDB has been updated with the following new features:

  • Citations recently published” and “NDA/BLAs recently enters” can retrieve citations and NDA/BLAs containing PGx data only
  • The above result pages show if the citation or NDA/BLA contains in vitroin vivo, or PGx content
  • All the “In Vitro Parameter Queries” take multiple compounds
  • All query results now 
    • use the therapeutic class format of presenting two levels, e.g., “Antiemetics ⟶ Neurokinin-1 Receptor Antagonist”
    • both levels of the therapeutic class are links directed to the therapeutic class DDI risk assessment
    • drug names are now links if there is any DDI summary/QT summary/PK profile in their monographs

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

Watch our collection of short video tutorials

We have initiated a [How to]… Series of 2-min videos, to show how to search, explore, use, some specific content in DIDB. So far, we have recorded videos on combination drugs, racemate and enantiomers, QT interval prolongation, and drug monographs.

If you have in mind any information you find difficult to retrieve in DIDB, feel free to let us know at didbase@uw.edu. We will get back to you and can decide to explain it in a short video.

The videos are available in DIDB Resource Center. Please note that you must be signed in to access.

Watch our comprehensive DIDB demonstration

We have recorded a one-hour long video tutorial suitable as a refresher training or to kick-start the use of DIDB. It starts by introducing the different lists available in the Resource Center of DIDB and then, it shows how to retrieve the human in vitro metabolism and transport information using preformulated queries. Finally it presents the in vivo datasets and how to retrieve clinical PK-based information from drug-drug interaction, food-effect, organ impairment and pharmacogenetics studies.

The video is available in DIDB Resource Center. Please note that you must be signed in to access.

In vivo prediction tool available for evaluation

We are pleased to provide access to an innovative online tool: DDPred, developed by the University of Lyon, France, that uses an in vivo static mechanistic model to predict PK-based DDIs with hundreds of substrates and inhibitors/inducers and evaluates the impact of polymorphism.

The link to this application will be available to all DIDB users during a 6-month evaluation. Please take the time to test it and to provide your feedback in the online survey. We value your feedback! Thank you.

New features! Drug characteristics, advanced table search, and more

DIDB has been updated with the following new features:

  • Drug characteristics, e.g., substrate sensitivity, precipitant inhibition/induction potency, NTR, QT interval prolongation potential, are added into the drug monograph
  • A list of drugs with identified drug characteristics are presented in the Resource Center
  • “Advanced table search” function is added to filter the query results (in table view). See our updated video tutorial.

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New features! New filtering option on tables, in vitro transporter data in all drug queries, and more.

DIDB has been updated with the following new features:

  • Select filter added to Table view results
  • Query results presented in Table view first
  • Revised overall effect descriptions
  • Drug queries > Objects or Precipitants now support selecting multiple drugs (previous multiple objects/precipitants queries removed)
  • In vitro transport data added to all the Drug queries including Objects, Precipitants, and Object and precipitant Pair
  • In vitro transporter IC50 and Ki queries updated and % inhibition query added
  • In vivo transporter queries now take multiple elements
  • In vitro induction now has down regulation effect
  • FDA clinical index data updated

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!