Watch our comprehensive DIDB demonstration

We have recorded a one-hour long video tutorial suitable as a refresher training or to kick-start the use of DIDB. It starts by introducing the different lists available in the Resource Center of DIDB and then, it shows how to retrieve the human in vitro metabolism and transport information using preformulated queries. Finally it presents the in vivo datasets and how to retrieve clinical PK-based information from drug-drug interaction, food-effect, organ impairment and pharmacogenetics studies.

The video is available in DIDB Resource Center. Please note that you must be signed in to access.

In vivo prediction tool available for evaluation

We are pleased to provide access to an innovative online tool: DDPred, developed by the University of Lyon, France, that uses an in vivo static mechanistic model to predict PK-based DDIs with hundreds of substrates and inhibitors/inducers and evaluates the impact of polymorphism.

The link to this application will be available to all DIDB users during a 6-month evaluation. Please take the time to test it and to provide your feedback in the online survey. We value your feedback! Thank you.

New features! Drug characteristics, advanced table search, and more

DIDB has been updated with the following new features:

  • Drug characteristics, e.g., substrate sensitivity, precipitant inhibition/induction potency, NTR, QT interval prolongation potential, are added into the drug monograph
  • A list of drugs with identified drug characteristics are presented in the Resource Center
  • “Advanced table search” function is added to filter the query results (in table view). See our updated video tutorial.

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New features! New filtering option on tables, in vitro transporter data in all drug queries, and more.

DIDB has been updated with the following new features:

  • Select filter added to Table view results
  • Query results presented in Table view first
  • Revised overall effect descriptions
  • Drug queries > Objects or Precipitants now support selecting multiple drugs (previous multiple objects/precipitants queries removed)
  • In vitro transport data added to all the Drug queries including Objects, Precipitants, and Object and precipitant Pair
  • In vitro transporter IC50 and Ki queries updated and % inhibition query added
  • In vivo transporter queries now take multiple elements
  • In vitro induction now has down regulation effect
  • FDA clinical index data updated

Feel free to contact us if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New features! Full text search, food effect studies, and more

DIDB has been updated with the following new features:

Feel free to contact us at didbase@uw.edu if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!

New queries available for beta testing

New queries are now available for beta testing under “FDA Marker Queries”. They allow you to search for in vitro and clinical data for inhibitors of CYP markers, and, in a second step from the query results page, view clinical concentrations of each inhibitor.

We are looking forward to your feedback!

Upcoming release of new features on April 6, 2019!

The DIDB Team will release new features on Saturday April 6, 2019. The release includes the following improvements:

  • Revised home page with a new “Latest NDAs entered” section.
  • Added number of entries (studies) to standard citation info.
  • Added new monograph page for all compounds.
    • This new monograph page combines the previously separate PK summary, QT summary, and monograph into a single page.
    • What was formerly known as “Monograph” is now “DDI summary” and has been renamed throughout application.
    • New monograph page also aggregates some other additional information on each compound such as DIDB defined compound relationships, other properties from DIDB, and some selected external resources.
    • Every compound has a monograph page, but many compounds may not have a DDI, PK, or QT summary, so there may be very little information presented.
  • In Resource Center, added listings of all compounds in each therapeutic class, including DDI risk information.  This new therapeutic class information is a replacement for the DDI risk information which was presented in the Disease section.   The entire Disease section has been removed.
  • In Resource Center, added two new listings – all compounds with DDI Summaries and all compounds with PK Profiles.
  • Removed pdf product labels and replaced with link to Drugs@FDA when an NDA is related to the drug.

Do not hesitate to contact us at didbase@uw.edu if you have any feedback or questions!

New features have been implemented!

The following new features have been implemented:

  • New DRUG query where you can find all studies in DIDB for a given compound, including in vitro transporter data
  • Unified in vivo measurement types across all study types
  • Unified citation tree view of all in vivo studies
  • Measurement types now displayed in their proper subscript formats
  • Tree view now more easily viewable on phones
  • New “In Vivo Other Mechanism” sub-type of “PD interaction”

Do not hesitate to contact us if you have any questions or suggestions!

e-PKGene Version 2.0 released April 11th!

The DIDB program is pleased to announce the release of e-PKGene Version 2.0.

Please see this detailed description of the new features.

New features include:

  1. A new responsive design that works on phones and tablets.
  2. A set of new quantitative searches:

    • Users are now able to select a combination of factors (compounds, genes, ethnicities) to query for quantitative measurements. Tabular results are provided in % ∆ from the reference population’s measurements and provide both pharmacokinetic (PK) and pharmacodynamic (PD) data.
    • These results can be further refined by filtering individual columns by text or by a numerical range. Columns can also be reordered or hidden from view. With these tools, users can explore the initial result set and refine the data to their needs. The data then can be saved as a spreadsheet.
  3. New design for displaying full citation and NDA information:

    • For each study, all information has been condensed into a single, easy to understand table. Measurement data for the citation/NDA can be viewed in the same manner as the quantitative results query by clicking on the “% ∆ data” link in the description section.
    • At the top of the citation navigation menu, “PK”, “PD”, and “Side Effects” buttons are highlighted only if the citation contains data for it; one click on either button will hide the information which is not of interest.
      needs. The data then can be saved as a spreadsheet.
  4. Updated drug summaries