In June, we added 93 citations in DIDB, including 48 in vitro (with 16 articles published in June 2024) and 45 in vivo articles (with 41 articles published in June 2024).
3 NDAs approved in 2024, including ceftobiprole (ZEVTERA), danicopan (VOYDEYA), and mavorixafor (XOLREMDI), were also curated in DIDB.
You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.
As always, feel free to contact us if you have any questions or comments.
The DDI Marker Studies Knowledgebase has been updated in July 2024 and is available in the DIDB Resource Center.
Our Editorial Team has dedicated effort on identifying substrates and inhibitors for OAT1, OAT3, OCT2, MATE1, and MATE2-K transporters. In this update, we have added 29 substrates and inhibitors of these transporters. Overall, 60 compounds have been identified as substates, inhibitors, and inducers of CYP enzymes and various transporters, including P-gp, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1, and MATE2-K. Notably, two compounds are classified as sensitive substrates of CYP3A, and a compound previously considered a moderate CYP2D6 inhibitor is now recognized as a strong inhibitor based on recent DDI data. These compounds could potentially lead to significant drug interactions mediated by these CYPs.
To view a comprehensive list of additions and modifications, including new compounds and updates to existing entries, you may use the “Recent Update” column (Column AE) on the spreadsheet and select “yes.”
In addition to substrates, inhibitors and inducers of CYPs and transporters, the Knowledgebase provides useful information on the compounds therapeutic class, clinical recommended dosage, pharmacokinetics (e.g., dose proportionality accumulation ratio, time to steady-state), QT prolongation, and NTI characteristics.
As always, feel free to contact us if you have any questions or comments.
In May, we added 105 citations in DIDB, including 48 in vitro (with 27 articles published in April 2024) and 57 in vivo articles (with 37 articles published in April 2024).
6 NDA/BLAs approved in 2024, including aprocitentan (TRYVIO), nogapendekin alfa inbakicept (ANKTIVA), pegulicianine (LUMISIGHT), sotatercept (WINREVAIR), tovorafenib (OJEMDA), and vadadustat (VAFSEO), were also curated in DIDB.
You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.
As always, feel free to contact us if you have any questions or comments.
In April, we added 99 citations in DIDB, including 51 in vitro (with 16 articles published in April 2024) and 48 in vivo articles (with 28 articles published in April 2024).
2 NDAs approved in 2024, including givinostat (DUVYZAT) and resmetirom (REZDIFFRA), were also curated in DIDB.
You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.
As always, feel free to contact us if you have any questions or comments.
The DDI Marker Studies Knowledgebase has been updated in April 2024, and is available in the DIDB Resource Center.
Our Editorial Team had dedicated efforts on identifying inhibitors for BCPP and OATP1B1/1B3 transporters, revealing 22 inhibitors of these transporters among this update. In summary, 42 compounds were identified as substates, inhibitors, and inducers of CYP enzymes and transporters (P-gp, BCRP, and OATP1B1/3) in this update. Notably, 5 compounds were sensitive substrates, and 1 was a strong inhibitor, potentially leading to significant drug interactions mediated by CYP1A2, CYP2D6, and CYP3A.
For enhanced accessibility, we’ve introduced a “Recent Update” column (Column AE) on the spreadsheet. Simply select “yes” to view a comprehensive list of additions and modifications, including new compounds and updates to existing cells.
In addition to substrates, inhibitors and inducers of CYPs and transporters, the Knowledgebase provides useful information on the compounds therapeutic class, clinical recommended dosage, pharmacokinetics (e.g., dose proportionality accumulation ratio, time to steady-state), QT prolongation, and NTI characteristics.
As always, feel free to contact us if you have any questions or comments.
In March, we added 125 citations in DIDB, including 60 in vitro (with 13 articles published in March 2024) and 65 in vivo articles (with 33 articles published in March 2024).
3 NDA/BLAs approved in 2024, including cefepime and enmetazobactam (EXBLIFEP), letibotulimumtoxina (LETYBO), and tislelizumab (TEVIMBRA), were also curated in DIDB.
You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.
As always, feel free to contact us if you have any questions or comments.
In February, we added 119 citations in DIDB, including 57 in vitro (with 21 articles published in February 2024) and 62 in vivo articles (with 35 articles published in February 2024).
4 NDAs approved in 2023 and 1 NDA approved in 2024, including berdazimer (ZELSUVMI), birch triterpenes (FILSUVEZ), eplontersen (WAIHUA), iptacopan (FABHALTA), zuranolone (ZURZUVAE), were also curated in DIDB.
We are pleased to let you know that all the NDAs and BLAs approved in 2023 (n = 55) have been entered in DIDB.
You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.
As always, feel free to contact us if you have any questions or comments.
In January, we added 117 citations in DIDB, including 54 in vitro (with 21 articles published in January 2024) and 63 in vivo articles (with 39 articles published in January 2024).
6 NDA/BLAs approved in 2023, including capivasertib (TRUQAP), efbemalenograstim (RYZNEUTA), epcoritamab (EPKINLY), mirikizumab (OMVOH), nirogacestat (OGSIVEO), and rezafungin (REZZAYO), were also curated in DIDB.
You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.
As always, feel free to contact us if you have any questions or comments.
The DDI Marker Studies Knowledgebase has been updated in January 2024, and is available in the DIDB Resource Center.
In this update, 42 compounds were identified as substates, inhibitors, and inducers of CYP enzymes and transporters (P-gp, BCRP, and OATP1B1/3). Among them, 3 compounds were sensitive substrates, and 3 compounds were strong inhibitors, which could lead to strong drug interactions mediated by CYP1A2, CYP2C19, and CYP3A.
In addition to substrates, inhibitors and inducers of CYPs and transporters, the Knowledgebase provides useful information on the compounds therapeutic class, clinical recommended dosage, pharmacokinetics (e.g., dose proportionality accumulation ratio, time to steady-state), QT prolongation, and NTI characteristics.
As always, feel free to contact us if you have any questions or comments.
In December, we added 76 citations in DIDB, including 32 in vitro (with 22 articles published in December 2023) and 44 in vivo articles (with 36 articles published in December 2023).
5 NDA/BLAs approved in 2023, including fruquintinib (FRUZAQLA), gepirone (EXXUA), repotrectinib (AUGTYRO), toripalimab (LOQTORZI), vamorolone (AGAMREE), were also curated in DIDB.
You can check the citations that are recently published and entered in DIDB and all the NDAs/BLAs in DIDB.
As always, feel free to contact us if you have any questions or comments.