The March Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.
Do not hesitate to contact us with comments or suggestions.
News
All 2019 NDAs and BLAs now fully curated into DIDB
Data entry for drug therapies approved by FDA in 2019 is now complete. Among the 48 drugs (38 NDAs and 10 BLAs) approved last year, 39 (33 NDAs and 6 BLAs) have relevant in vitro and clinical findings related to DDI, PGx, food effect, and/or organ impairment. Drug monographs are also available, summarizing key DDI results, QT, and PK information.
The full list of NDA/BLAs entered in DIDB can be found at https://didb.druginteractionsolutions.org/resources/all-ndas/
Do not hesitate to contact us with comments or suggestions.
New features! Full text search, food effect studies, and more.
DIDB has been updated with the following new features:
- New full text search of all our citations, monographs, and resources; that’s 23,000 pages.
- New in vivo queries to retrieve food effect studies. Find queries in object query in PK section and AUC/CL change query. Food effect badge added to citations throughout DIDB when the citation contains a food effect study.
- New all monographs and all QT summaries pages.
- Better organized home and all queries pages. Menu as been changed to reflect these.
- The find all studies for a compound query is now lighting fast.
- All queries in the PK section now take multiple compounds.
- Semantic Scholar links have been added when citation exists in Semantic Scholar (an Allen Institute for AI project).
Feel free to contact us at didbase@uw.edu if you experience any issues or if you have any questions or suggestions. Your feedback is always greatly valued!
February Newsletter
The February Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.
Do not hesitate to contact us with comments or suggestions.
Finalized FDA DDI guidances now available in the DIDB Resource Center
New finalized In Vitro & Clinical Drug Interaction Studies FDA guidances (January 2020) are now available in the DIDB Resource Center. Please note that you must be signed in to access.
Lists of Sensitive Substrates, Inhibitors and Inducers updated + New Combined List
The lists of sensitive substrates, inhibitors, and inducers have been updated and are available in the Resource Center.
Note that we are working on improving the consistency of the presentation so you may notice small changes in some of the drug names or therapeutic classes. Also, for the same reason, we are now presenting all changes in exposure as AUC ratios.
Finally, you will find a new Excel file, combining all the information, so that you can search easily using any of the headings (drug name, therapeutic class, CYP…). Any feedback on this new combined file is welcome!
As always, feel free to contact us if you have any questions or comments.
January Newsletter
The January Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.
Do not hesitate to contact us with comments or suggestions.
December Newsletter
The December Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.
Do not hesitate to contact us with comments or suggestions.
November Newsletter
The November Newsletter is now available. You can see this and past newsletters in the DIDB Resource Center. Please note that you must be signed in to access.
Do not hesitate to contact us with comments or suggestions.
Lists of Sensitive Substrates, Inhibitors and Inducers updated
The lists of sensitive substrates, inhibitors, and inducers have been updated and are available in the Resource Center.
As always, feel free to contact us if you have any questions or comments.