We are excited to announce the updated DDI Calculator, featuring enhancements designed to improve usability, transparency, and regulatory alignment.
What’s New in this version:
- ICH M12 Compliance by Default
The calculator aligns with ICH M12 guideline, supporting standardized and regulatory-consistent DDI assessments. - Administration Route Options
Users can select between oral and parenteral routes of administration, enabling more accurate and scenario-specific predictions. - Expanded Enzyme and Transporter Coverage
UGTs and hepatic efflux transporters are now shown by default, with the option to include additional enzymes and transporters as needed. - Multiple Lots per Enzyme (Induction Module)
The induction module now supports multiple lots per enzyme, allowing for more robust and representative data inputs. - Enhanced Parameter Guidance
Contextual footnotes across the tool provide clearer direction for selecting parameters and using inputs correctly. - Intermediate Values Displayed
Greater transparency is achieved with the display of intermediate calculation values, e.g., Cmax,u, Cmat,inlet,u, helping users better understand how results are derived.
These updates are designed to make the DDI Calculator more powerful, flexible, and aligned with current scientific and regulatory expectations.
We encourage you to explore the new features and share your feedback. If you have any questions or would like a walkthrough of the updates, please don’t hesitate to reach out.